International Research Journal of Education and Technology

To improve the half-life and bioavailability we have designed twice daily mini-tablets formulation of cholin feno fibrate. The system comprises of 6 matrix mini-tablets weighing 25 mg encapsulated in HPMC capsule (size1). For achieving the sustain releaseprofile, various viscosity grades of Hydroxy propyl methyl cellulose polymer (HPMC K4M, K15M, K100M) were used. The mini -tablets wereprepared by direct-compression method. The prepared mini-tablets were subjected for pre-compressional and post-compressional parameters. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All the postcompressionalparameter evaluated were within acceptable limits. The in-vitro performance of our best mini-tablets formulation showed the desired behavior, nearly 99.57 % of drug was sustained for a period of 12 hrs.